The F16 antibody, specific to the extra-domain A1 of tenascin-C, is being used in SIP format for PET immunodetection of malignancies and other serious conditions. Iodine-124 has been chosen as the preferred positron emitting radionuclide, in view of its ideal physical properties for tomographic imaging applications and of its half-life, which nicely matches the one of the antibody clearance from tissues and from circulation.

Modern PET technologies allow the detection of lesions with a diameter of a few millimeters. Tenapet may facilitate the early diagnosis of disease, the assessment of minimal residual disease and therapy planning with F16-based drugs.

SELECTED REFERENCES
Tijink et al., (2009), Eur. J. Nucl. Med. Mol. Imag., 36, 1235-1244;
Marlind et al. (2008) Clin. Cancer Res.,14, 6515-24;
Brack et al. (2006) Clin. Cancer Res., 12, 3200-3208.

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