PHC-102 is a 99mTc labelled small molecule radiotracer for the non-invasive detection of carbonic anhydrase IX (CAIX) expressing solid tumors.
The product consists of a CAIX ligand derived from acetazolamide, a linker and a peptide 99mTC chelator.
CAIX is a validated target, which is expressed in the majority of Renal Cell Carcinoma (RCC) patients, but also in a proportion of patients with other malignancies (e.g., ~30% of patients with Colorectal Carcinoma).
In preclinical studies, PHC-102 demonstrated high tumor uptake and tumor-to-kidney ratios of up to 3.
This favorable selectivity may allow imaging of tumors in the kidney and distant sites at earlier time points than commonly possible with antibody-based products.
The product has recently entered Phase I clinical development in patients with RCC.
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