Dodekin is a fully-human antibody-cytokine fusion consisting of the immunostimulatory cytokine interleukin 12 (IL12) fused to a human vascular targeting antibody. IL12 has potent anti-cancer activity, but its therapeutic use is limited by associated toxicities. However, the site-selective delivery of IL12 to the sub-endothelial extracellular matrix in tumor blood vessels allows to drastically improve the therapeutic index of this cytokine. Furthermore, the newly developed single-chain format of the antibody-cytokine fusion greatly improves the process development of Dodekin.
Quantitative biodistribution studies of Dodekin have shown a preferential uptake of the molecule in tumor tissues compared to healthy organs and our pre-clinical work shows that the immunocytokine has a potent anti-tumor activity in several immunocompetent murine models of cancer. Dodekin is able to induce long-lasting tumor eradication when administered in combination with paclitaxel, and potentiates the action of other therapeutic agents such immunological checkpoint inhibitors.
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