Fibromun (L19-TNF) is a fully-human immunostimulatory product, currently being tested in clinical trials in patients with cancer. It consists of the anti-EDB human antibody L19, fused to human TNF, a strong pro-inflammatory cytokine. Recombinant TNF (Beromun TM, Boehringer Ingelheim) has so far been approved only for certain clinical applications.
Fibromun has previously been studied in clinical trials in melanoma in the isolated limb-perfusion setting and in a systemic clinical trial.
A pivotal clinical trial for Fibromun in combination with doxorubicin in metastatic Soft Tissue Sarcoma is started in Europe and is about to start in the USA.
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